anti-TLR2 mAb (ABM3A87) (FITC)
| Code | Size | Price |
|---|
| AG-20T-0300F-C100 | 100 ug | £355.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Fluorescence-activated cell sorting (FACS)
Shipping:
+4°C
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
Toll-like Receptor 2; CD282; Toll/Interleukin-1 Receptor-like Protein 4; TIL4
Concentration:
0.2mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide.
Handling Advice:
Do not freeze.Protect from light.
Immunogen:
Recombinant human TLR2 protein (aa 180-420).
Labels - Conjugates:
FITC
Long Description:
Monoclonal Antibody. Recognizes human and mouse TLR2. Isotype: Mouse IgG1kappa. Clone: ABM3A87. Applications: FACS. Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide. TLR2 (Toll-like Receptor 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR2 resides on the plasma membrane where it responds to lipid-containing pathogen-associated molecular patterns (PAMPs), such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipopeptides. It does this by forming dimeric complexes with either TLR1 or TLR6, which consequently is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infections with these pathogens. TLR2 also interacts with a large number of non-TLR molecules such as LY96 (MD-2), allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial and epithelial cells.
Package Type:
Plastic Vial
Product Description:
TLR2 (Toll-like Receptor 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR2 resides on the plasma membrane where it responds to lipid-containing pathogen-associated molecular patterns (PAMPs), such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipopeptides. It does this by forming dimeric complexes with either TLR1 or TLR6, which consequently is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infections with these pathogens. TLR2 also interacts with a large number of non-TLR molecules such as LY96 (MD-2), allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial and epithelial cells.
Purity:
Protein G purified.
Specificity:
Recognizes human and mouse TLR2.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibody Conjugates
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 6 months after receipt when stored at +4°C.