anti-TLR9 mAb (ABM1C51) (R-PE)
| Code | Size | Price |
|---|
| AG-20T-0308R-C100 | 100 ug | £370.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Fluorescence-activated cell sorting (FACS)
Shipping:
+4°C
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
Toll-like Receptor 9; CD289
Concentration:
0.2mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.05% sodium azide.
Handling Advice:
Do not freeze.Protect from light.
Immunogen:
Recombinant human TLR9 protein (aa 100-290).
Labels - Conjugates:
R-PE
Long Description:
Monoclonal Antibody. Recognizes human and mouse TLR9. Isotype: Mouse IgG1kappa. Clone: ABM1C51. Applications: FACS. Liquid. In PBS containing 0.05% sodium azide. TLR9 (Toll-like Receptor 9) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR9 is expressed by numerous cells of the immune system such as B lymphocytes, monocytes, natural killer (NK) cells and plasmacytoid dendritic cells. It is expressed intracellularly, within the endosomal compartments and functions to alert the immune system of viral and bacterial infections by binding to DNA rich in CpG motifs. This nucleotide-sensing TLR is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (also called oligodinucleotides, ODNs), and consequently signals via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response and eventually activation of a Th1-biased adaptive immune attack. Specific TLR9 agonists have been shown to have substantial antitumor activity, making the TLR9 signaling pathway an interesting target for therapeutic research.
Package Type:
Plastic Vial
Product Description:
TLR9 (Toll-like Receptor 9) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR9 is expressed by numerous cells of the immune system such as B lymphocytes, monocytes, natural killer (NK) cells and plasmacytoid dendritic cells. It is expressed intracellularly, within the endosomal compartments and functions to alert the immune system of viral and bacterial infections by binding to DNA rich in CpG motifs. This nucleotide-sensing TLR is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (also called oligodinucleotides, ODNs), and consequently signals via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response and eventually activation of a Th1-biased adaptive immune attack. Specific TLR9 agonists have been shown to have substantial antitumor activity, making the TLR9 signaling pathway an interesting target for therapeutic research.
Purity:
Protein G purified.
Specificity:
Recognizes human and mouse TLR9.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibody Conjugates
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 6 months after receipt when stored at +4°C.