anti-TLR6 (human) mAb (ABM1B50)
| Code | Size | Price |
|---|
| AG-20T-0305-C100 | 100 ug | £340.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Western Blot (WB)
Shipping:
-20°C
Storage:
Short Term: 4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Toll-like Receptor 6; CD286
Concentration:
0.5mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human TLR6 protein (aa 280-512).
Long Description:
Monoclonal Antibody. Recognizes human TLR6. Isotype: Mouse IgG1kappa. Clone: ABM1B50. Applications: FACS, WB. Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. TLR6 (Toll-like Receptor 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 in complex with TLR2 specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides from Gram-positive bacteria and fungi. The activation cluster TLR2:TLR6:CD14:CD36 signals via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. In complex with TLR2 recognizes MALP-2, STF, PSM and OspA-L, as well. In response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, TLR6 forms a heterodimer with TLR4. This complex rapidly internalizes and triggers inflammatory responses through the NF-kappaB-dependent MYD88 signaling or via TICAM1 signaling pathways. The complex promotes sterile inflammation in monocytes/macrophages. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Various polymorphism have been associated with inflammatory and tumor pathologies.
Package Type:
Plastic Vial
Product Description:
TLR6 (Toll-like Receptor 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 in complex with TLR2 specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides from Gram-positive bacteria and fungi. The activation cluster TLR2:TLR6:CD14:CD36 signals via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. In complex with TLR2 recognizes MALP-2, STF, PSM and OspA-L, as well. In response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, TLR6 forms a heterodimer with TLR4. This complex rapidly internalizes and triggers inflammatory responses through the NF-kappaB-dependent MYD88 signaling or via TICAM1 signaling pathways. The complex promotes sterile inflammation in monocytes/macrophages. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Various polymorphism have been associated with inflammatory and tumor pathologies.
Purity:
Protein G purified.
Specificity:
Recognizes human TLR6.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C.