anti-TLR10 (human) mAb (ABM3C85)
| Code | Size | Price |
|---|
| AG-20T-0310-C100 | 100 ug | £340.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
-20°C
Storage:
Short Term: 4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Toll-like Receptor 10; CD290
Concentration:
0.5mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human TLR10 protein (aa 100-369).
Long Description:
Monoclonal Antibody. Isotype: Mouse IgG2akappa. Clone: ABM3C85. Applications: WB. Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. TLR10 (Toll-like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1beta specifically after exposure to TLR2 ligands. Like TLR1 and TLR6, TLR10 has also been shown to form a heterodimer complex with TLR2 during Helicobacter pylori infection and that it could be involved in the recognition of FSL-1, LPS and flagellin. TLR10 is an important innate immune sensor of viral infection with a role in innate immune defense and immunopathology following viral and bacterial pathogen infection.
Package Type:
Plastic Vial
Product Description:
TLR10 (Toll-like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1beta specifically after exposure to TLR2 ligands. Like TLR1 and TLR6, TLR10 has also been shown to form a heterodimer complex with TLR2 during Helicobacter pylori infection and that it could be involved in the recognition of FSL-1, LPS and flagellin. TLR10 is an important innate immune sensor of viral infection with a role in innate immune defense and immunopathology following viral and bacterial pathogen infection.
Purity:
Protein G purified.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C.