anti-OX40L (human) mAb (rec.) (blocking) (R4930) (preservative free)
| Code | Size | Price |
|---|
| AG-27B-6001PF-C100 | 100 ug | £300.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Recombinant Antibody
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Functional Study
Shipping:
-20°C
Storage:
Short Term: 4°C Long Term: -20°C
Further Information
Alternate Names/Synonyms:
CD252; CD134L; OX40 Ligand; TNFSF4; Tumor Necrosis Factor Superfamily Member 4; TAX Transcriptionally-activated Glycoprotein 1; TXGP1; gp34
Concentration:
1mg/ml
EClass:
32160000
Endotoxin:
<0.001EU/µg
Form (Short):
liquid
Formulation:
Liquid. In PBS.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
Recombinant human OX40L.
Labels - Conjugates:
Preservative Free
Long Description:
Recombinant Antibody. Recognizes human OX40L. Species cross-reactivity: Human. Clone: R4930. Isotype: Human IgG1kappa. Applications: FACS, FUNC, FUNC (Blocking). Host: CHO cells. Liquid. In PBS. OX40L is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium.
NCBI, Uniprot Number:
P23510
Other data:
This antibody is a biosimilar generically called Oxelumab (CAS 1186098-83-8) and originally developed by Genentech. Oxelumab is a OX40 ligand blocker designed for the prevention of allergen-induced airway inflammation in adults with mild asthma. Potentially other application areas are transplantation and autoimmunity research or protection against inflammation-driven fibrosis.
Package Type:
Plastic Vial
Product Description:
OX40L [CD252; CD134L] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium.
Purity:
>95% (SDS-PAGE)
Source / Host:
CHO cells
Specificity:
Recognizes human OX40L.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.
References
In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation: D. Seshasayee, et al.; J. Clin. Invest. 117, 3868 (2007) | Monoclonal antibodies for the treatment of asthma: M.C. Catley, et al.; Pharm. Ther. 132, 333 (2011) | OX40L blockade and allergen-induced airway responses in subjects with mild asthma: G.M. Gauvreau, et al.; Clin. Exp. Allergy 44, 29 (2014)