KW-2449 hydrochloride
| Code | Size | Price |
|---|
| SYN-1205-M100 | 100 mg | Enquire |
Quantity:
| SYN-1205-M001 | 1 mg | £69.00 |
Quantity:
| SYN-1205-M005 | 5 mg | £92.00 |
Quantity:
| SYN-1205-M010 | 10 mg | £115.00 |
Quantity:
| SYN-1205-M050 | 50 mg | £326.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
KW2449
Appearance:
Solid.
CAS:
841259-17-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C20H20N4O.ClH/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19;/h1-10,21H,11-14H2,(H,22,23);1H/b10-7+;
InChiKey:
RTGZMIHOFOOYEY-HCUGZAAXSA-N
Long Description:
Chemical. CAS: 841259-17-4. Formula: C20H20N4O . HCl. MW: 332.4 . 36.5. KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRbeta, IGF-1R, EGFR.
Molecular Formula:
C20H20N4O . HCl
Molecular Weight:
332.4 . 36.5
Package Type:
Plastic Vial
Product Description:
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRbeta, IGF-1R, EGFR.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation: Y. Shiotsu, et al.; Blood 114, 1607 (2009)
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