Canertinib
| Code | Size | Price |
|---|
| SYN-1030-M100 | 100 mg | Enquire |
Quantity:
| SYN-1030-M001 | 1 mg | £69.00 |
Quantity:
| SYN-1030-M005 | 5 mg | £86.00 |
Quantity:
| SYN-1030-M010 | 10 mg | £92.00 |
Quantity:
| SYN-1030-M050 | 50 mg | £315.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
CI1033; PD-183805
Appearance:
Solid.
CAS:
267243-28-7
Class:
9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS05,GHS08,GHS09
Hazards:
H318, H373, H402
InChi:
InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
InChiKey:
OMZCMEYTWSXEPZ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 267243-28-7. Formula: C24H25ClFN5O3. MW: 486. Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4.
Molecular Formula:
C24H25ClFN5O3
Molecular Weight:
486
Package Type:
Plastic Vial
Precautions:
P280, P273, P260, P314, P305, P351, P338
Product Description:
Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4.
Purity:
>95%
Signal word:
Danger
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UN Nummer:
UN 3077
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux: C. Erlichman, et al.; Cancer Res. 61, 739 (2001)
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