PP242
| Code | Size | Price |
|---|
| SYN-1181-M100 | 100 mg | Enquire |
Quantity:
| SYN-1181-M001 | 1 mg | £69.00 |
Quantity:
| SYN-1181-M005 | 5 mg | £92.00 |
Quantity:
| SYN-1181-M010 | 10 mg | £139.00 |
Quantity:
| SYN-1181-M050 | 50 mg | £438.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
PP-242
Appearance:
Solid.
CAS:
1092351-67-1
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)
InChiKey:
MFAQYJIYDMLAIM-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1092351-67-1. Formula: C16H16N6O. MW: 308.3. PP242 exhibits potent selectivity for mTOR over other PI3K family kinases such as p110 alpha - delta and DNA-PK, with IC(50) of 1.96µM, 2.2µM, 1.27µM, 0.102µM, and 0.408µM, respectively.
Molecular Formula:
C16H16N6O
Molecular Weight:
308.3
Package Type:
Plastic Vial
Product Description:
PP242 exhibits potent selectivity for mTOR over other PI3K family kinases such as p110 alpha - delta and DNA-PK, with IC(50) of 1.96µM, 2.2µM, 1.27µM, 0.102µM, and 0.408µM, respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases: B. Apsel, et al.; Nat. Chem. Biol. 4, 691 (2008) | Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment: Z. Zeng, et al.; Blood 120, 2679 (2012)