TG101348
| Code | Size | Price |
|---|
| SYN-1104-M100 | 100 mg | Enquire |
Quantity:
| SYN-1104-M001 | 1 mg | £80.00 |
Quantity:
| SYN-1104-M005 | 5 mg | £115.00 |
Quantity:
| SYN-1104-M010 | 10 mg | £186.00 |
Quantity:
| SYN-1104-M050 | 50 mg | £572.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
SAR-302503
Appearance:
Solid.
CAS:
936091-26-8
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
InChiKey:
JOOXLOJCABQBSG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 936091-26-8. Formula: C27H36N6O3S. MW: 524.7. TG101348 inhibits JAK2(V617F) with an IC(50) of 3nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2(V617F) cells.
Molecular Formula:
C27H36N6O3S
Molecular Weight:
524.7
Package Type:
Plastic Vial
Product Description:
TG101348 inhibits JAK2(V617F) with an IC(50) of 3nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2(V617F) cells.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera: G. Wernig, et al.; Cancer Cell 13, 311 (2008)
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