BKM120
| Code | Size | Price |
|---|
| SYN-1200-M100 | 100 mg | Enquire |
Quantity:
| SYN-1200-M001 | 1 mg | £80.00 |
Quantity:
| SYN-1200-M005 | 5 mg | £115.00 |
Quantity:
| SYN-1200-M010 | 10 mg | £151.00 |
Quantity:
| SYN-1200-M050 | 50 mg | £467.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
NVP-BKM120
Appearance:
Solid.
CAS:
944396-07-0
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)
InChiKey:
CWHUFRVAEUJCEF-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 944396-07-0. Formula: C18H21F3N6O2. MW: 410.4. NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3Kalpha Inhibitor with IC(50) of 20nM, currently in Phase II clinical trials for the treatment of cancer. It exhibits lower potency against class III and class IV PI3Ks.
Molecular Formula:
C18H21F3N6O2
Molecular Weight:
410.4
Package Type:
Plastic Vial
Product Description:
NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3Kalpha Inhibitor with IC(50) of 20nM, currently in Phase II clinical trials for the treatment of cancer. It exhibits lower potency against class III and class IV PI3Ks.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment: Z. Zeng, et al.; Blood 120, 2679 (2012)
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