NVP-BGJ398
| Code | Size | Price |
|---|
| SYN-1152-M100 | 100 mg | Enquire |
Quantity:
| SYN-1152-M001 | 1 mg | £80.00 |
Quantity:
| SYN-1152-M005 | 5 mg | £133.00 |
Quantity:
| SYN-1152-M010 | 10 mg | £203.00 |
Quantity:
| SYN-1152-M050 | 50 mg | £461.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
NVPBGJ398
Appearance:
Solid.
CAS:
872511-34-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
InChiKey:
QADPYRIHXKWUSV-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 872511-34-7. Formula: C26H31Cl2N7O3. MW: 560.5. NVP-BGJ398 inhibits FGFR-WT, FGFR2-WT, FGFR3-K650E, FGFR3-S249C and FGFR4-WT with IC(50) values of 4.6, 4.9, 5, 5 and 168nM, respectively.
Molecular Formula:
C26H31Cl2N7O3
Molecular Weight:
560.5
Package Type:
Plastic Vial
Product Description:
NVP-BGJ398 inhibits FGFR-WT, FGFR2-WT, FGFR3-K650E, FGFR3-S249C and FGFR4-WT with IC(50) values of 4.6, 4.9, 5, 5 and 168nM, respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase: V. Guagnano, et al.; J. Med. Chem. 54, 7066 (2011)