BMS-387032 hydrochloride
| Code | Size | Price |
|---|
| SYN-1080-M100 | 100 mg | Enquire |
Quantity:
| SYN-1080-M001 | 1 mg | £86.00 |
Quantity:
| SYN-1080-M005 | 5 mg | £139.00 |
Quantity:
| SYN-1080-M010 | 10 mg | £215.00 |
Quantity:
| SYN-1080-M050 | 50 mg | £719.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
BMS387032; SNS-032
Appearance:
Solid.
CAS:
345627-90-9
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C17H24N4O2S2.ClH/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11;/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22);1H
InChiKey:
PKCYFIUOIGVHLX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 345627-90-9. Formula: C17H24N4O2S2 . HCl. MW: 380.5 . 36.5. BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It has little effect on CDK6.
Molecular Formula:
C17H24N4O2S2 . HCl
Molecular Weight:
380.5 . 36.5
Package Type:
Plastic Vial
Product Description:
BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It has little effect on CDK6.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent: R.N. Misra, et al.; J. Med. Chem. 47, 1719 (2004)
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