BX-795
| Code | Size | Price |
|---|
| SYN-1026-M100 | 100 mg | Enquire |
Quantity:
| SYN-1026-M001 | 1 mg | £86.00 |
Quantity:
| SYN-1026-M005 | 5 mg | £127.00 |
Quantity:
| SYN-1026-M010 | 10 mg | £168.00 |
Quantity:
| SYN-1026-M050 | 50 mg | £643.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
BX795
Appearance:
Solid.
CAS:
702675-74-9
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
InChiKey:
VAVXGGRQQJZYBL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 702675-74-9. Formula: C23H26IN7O2S. MW: 591.5. BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC(50) 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-epsilon. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC(50) values ranging from submicromolar amounts (0.368µM to greater than 450µM.
Molecular Formula:
C23H26IN7O2S
Molecular Weight:
591.5
Package Type:
Plastic Vial
Product Description:
BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC(50) 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-epsilon. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC(50) values ranging from submicromolar amounts (0.368µM to greater than 450µM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1: R.I. Feldmann, et al.; J. Biol. Chem. 280, 19867 (2005) | The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007) | Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation: K. Clark, J. Biol. Chem. 284, 14136 (2009)
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