S49076 HCl
| Code | Size | Price |
|---|
| SYN-1217-M100 | 100 mg | Enquire |
Quantity:
| SYN-1217-M050 | 50 mg | Enquire |
Quantity:
| SYN-1217-M001 | 1 mg | £104.00 |
Quantity:
| SYN-1217-M005 | 5 mg | £186.00 |
Quantity:
| SYN-1217-M010 | 10 mg | £303.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short Term: +4°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
S-49076 . HCl; (Z)-3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione hydrochloride
Appearance:
Solid.
CAS:
1265965-19-2
EClass:
32160000
Form (Short):
liquid
Hazards:
H303, H317, H333
InChi:
InChI=1S/C22H22N4O4S.ClH/c27-20-13-31-22(29)26(20)12-14-1-2-19-17(8-14)18(21(28)24-19)9-16-7-15(10-23-16)11-25-3-5-30-6-4-25;/h1-2,7-10,23H,3-6,11-13H2,(H,24,28);1H/b18-9-;
InChiKey:
FPSAJUOIYZSJJA-NAIZSXBXSA-N
Long Description:
Chemical. CAS: 1265965-19-2. Formula: C22H23ClN4O4S. MW: 475. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block MET-driven migration of lung carcinoma cells, and inhibit colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. S49076 has also been shown to cause tumour growth arrest in bevacizumab-resistant tumours in xenograft models.
Molecular Formula:
C22H23ClN4O4S
Molecular Weight:
475
Package Type:
Plastic Vial
Product Description:
S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block MET-driven migration of lung carcinoma cells, and inhibit colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. S49076 has also been shown to cause tumour growth arrest in bevacizumab-resistant tumours in xenograft models.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab: M.F. Burbridge, et al.; Mol. Cancer Ther. 12, 1749 (2013)
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