AT9283
| Code | Size | Price |
|---|
| SYN-1011-M100 | 100 mg | Enquire |
Quantity:
| SYN-1011-M001 | 1 mg | £104.00 |
Quantity:
| SYN-1011-M005 | 5 mg | £186.00 |
Quantity:
| SYN-1011-M010 | 10 mg | £303.00 |
Quantity:
| SYN-1011-M050 | 50 mg | £877.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
AT-9283
Appearance:
Solid.
CAS:
896466-04-9
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27)
InChiKey:
LOLPPWBBNUVNQZ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 896466-04-9. Formula: C19H23N7O2. MW: 381.4. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM.
Molecular Formula:
C19H23N7O2
Molecular Weight:
381.4
Package Type:
Plastic Vial
Product Description:
Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity: S. Howard, et al.; J. Med. Chem. 52, 379 (2009) | Discovery and development of aurora kinase inhibitors as anticancer agents: J.R. Pollard & M. Mortimore; J. Med. Chem. 52, 2629 (2009) | Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors: Y. Zheng, et al.; Bioorg. Med. Chem. Lett. 23, 3523 (2013)
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