AZD-7762 hydrochloride
| Code | Size | Price |
|---|
| SYN-1017-M100 | 100 mg | Enquire |
Quantity:
| SYN-1017-M001 | 1 mg | £104.00 |
Quantity:
| SYN-1017-M005 | 5 mg | £127.00 |
Quantity:
| SYN-1017-M010 | 10 mg | £197.00 |
Quantity:
| SYN-1017-M050 | 50 mg | £584.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
AZD7762
Appearance:
Solid.
CAS:
1246094-78-9
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1
InChiKey:
WFZBLOIXZRZEDG-YDALLXLXSA-N
Long Description:
Chemical. CAS: 1246094-78-9. Formula: C17H19FN4O2S . HCl. MW: 362.4 . 36.5. Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies. AZD7762 is a specific inhibitor for the CHK1/2 kinases with IC(50) values less than 10. AZD7762 enhances radiation sensitivity and gemcitabine-mediated radiosensitization in pancreatic cancer cells and xenografts and thus is helpful in the treatments of potentially many cancers. In addition, AZD7762 is a chemosensitizer and with gemcitabine and radiation produced a significant delay in the growth of pancreatic tumor xenografts with tolerable toxicity. AZD7762 is being studied as an important link in improving both adjuvant therapy and the treatment of metastatic disease.
Molecular Formula:
C17H19FN4O2S . HCl
Molecular Weight:
362.4 . 36.5
Package Type:
Plastic Vial
Product Description:
Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies. AZD7762 is a specific inhibitor for the CHK1/2 kinases with IC(50) values less than 10. AZD7762 enhances radiation sensitivity and gemcitabine-mediated radiosensitization in pancreatic cancer cells and xenografts and thus is helpful in the treatments of potentially many cancers. In addition, AZD7762 is a chemosensitizer and with gemcitabine and radiation produced a significant delay in the growth of pancreatic tumor xenografts with tolerable toxicity. AZD7762 is being studied as an important link in improving both adjuvant therapy and the treatment of metastatic disease.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair: M.A. Morgan, et al.; Cancer Res. 70, 4972 (2010) | Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas: V. Oza, et al.; J. Med. Chem. 55, 5130 (2012)