SB590885
| Code | Size | Price |
|---|
| SYN-1077-M100 | 100 mg | Enquire |
Quantity:
| SYN-1077-M001 | 1 mg | £104.00 |
Quantity:
| SYN-1077-M005 | 5 mg | £162.00 |
Quantity:
| SYN-1077-M010 | 10 mg | £209.00 |
Quantity:
| SYN-1077-M050 | 50 mg | £777.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
SB-590885
Appearance:
Solid.
CAS:
405554-55-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24+
InChiKey:
MLSAQOINCGAULQ-QFMPWRQOSA-N
Long Description:
Chemical. CAS: 405554-55-4. Formula: C27H27N5O2. MW: 453.5. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity.
Molecular Formula:
C27H27N5O2
Molecular Weight:
453.5
Package Type:
Plastic Vial
Product Description:
SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885: A.J. King, et al.; Cancer Res. 66, 11100 (2006) | The combination of RAF265, SB590885, ZSTK474 on thyroid cancer cell lines deeply impact on proliferation and MAPK and PI3K/Akt signaling pathways: S. Barollo, et al.; Invest. New Drugs 32, 626 (2014)
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