SGI-1776
| Code | Size | Price |
|---|
| SYN-1193-M100 | 100 mg | Enquire |
Quantity:
| SYN-1193-M001 | 1 mg | £104.00 |
Quantity:
| SYN-1193-M005 | 5 mg | £162.00 |
Quantity:
| SYN-1193-M010 | 10 mg | £268.00 |
Quantity:
| SYN-1193-M050 | 50 mg | £848.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
4°C
Documents
Further Information
Alternate Names/Synonyms:
SGI1776
Appearance:
Solid.
CAS:
1025065-69-3
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
InChiKey:
MHXGEROHKGDZGO-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1025065-69-3. Formula: C20H22F3N5O. MW: 405.4. SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. SGI-1776 inhibits FLT3 kinase as well, which can complicate some experimental results if not carefully controlled.
Molecular Formula:
C20H22F3N5O
Molecular Weight:
405.4
Package Type:
Plastic Vial
Product Description:
SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. SGI-1776 inhibits FLT3 kinase as well, which can complicate some experimental results if not carefully controlled.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.
References
Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia: L.S. Chen, et al.; Blood 118, 693 (2011) | Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors: J. Pastor, et al.; Bioorg. Med. Chem. Lett. 22, 1591 (2012)
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