GDC-0032
| Code | Size | Price |
|---|
| SYN-1202-M100 | 100 mg | Enquire |
Quantity:
| SYN-1202-M001 | 1 mg | £104.00 |
Quantity:
| SYN-1202-M005 | 5 mg | £151.00 |
Quantity:
| SYN-1202-M010 | 10 mg | £244.00 |
Quantity:
| SYN-1202-M050 | 50 mg | £771.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
GDC0032
Appearance:
Solid.
CAS:
1282512-48-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
InChiKey:
BEUQXVWXFDOSAQ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1282512-48-4. Formula: C24H28N8O2. MW: 460.5. GDC-0032 is a potent, next-generation beta isoform-sparing PI3K inhibitor targeting PI3Kalpha/delta/gamma with Ki of 0.29nM/0.12nM/0.97nM, >10 fold selective over PI3Kbeta.
Molecular Formula:
C24H28N8O2
Molecular Weight:
460.5
Package Type:
Plastic Vial
Product Description:
GDC-0032 is a potent, next-generation beta isoform-sparing PI3K inhibitor targeting PI3Kalpha/delta/gamma with Ki of 0.29nM/0.12nM/0.97nM, >10 fold selective over PI3Kbeta.
Purity:
>95%
Solubility Chemicals:
Slightly soluble (<1mg/ml) in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a beta-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity: C.O. Ndubaku, et al.; J. Med. Chem. 56, 4597 (2013)
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