GSK2606414
| Code | Size | Price |
|---|
| SYN-1201-M100 | 100 mg | Enquire |
Quantity:
| SYN-1201-M001 | 1 mg | £115.00 |
Quantity:
| SYN-1201-M005 | 5 mg | £197.00 |
Quantity:
| SYN-1201-M010 | 10 mg | £303.00 |
Quantity:
| SYN-1201-M050 | 50 mg | £818.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
GSK-2606414
Appearance:
Solid.
CAS:
1337531-36-8
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)
InChiKey:
SIXVRXARNAVBTC-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1337531-36-8. Formula: C24H20F3N5O. MW: 451.4. GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC(50) of 0.4nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.
Molecular Formula:
C24H20F3N5O
Molecular Weight:
451.4
Package Type:
Plastic Vial
Product Description:
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC(50) of 0.4nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK): J.M. Axten, et al.; J. Med. Chem. 55, 7193 (2012)
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