E7080
| Code | Size | Price |
|---|
| SYN-1038-M100 | 100 mg | Enquire |
Quantity:
| SYN-1038-M001 | 1 mg | £115.00 |
Quantity:
| SYN-1038-M005 | 5 mg | £174.00 |
Quantity:
| SYN-1038-M010 | 10 mg | £268.00 |
Quantity:
| SYN-1038-M050 | 50 mg | £877.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
E-7080; Lenvatinib
Appearance:
Solid.
CAS:
417716-92-8
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
InChiKey:
WOSKHXYHFSIKNG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 417716-92-8. Formula: C21H19ClN4O4. MW: 426.9. E7080 is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. It is most potent against VEGFR2(KDR)/VEGFR3(Flt-4), with IC(50) values of 4nM and 5.2nM respectively.
Molecular Formula:
C21H19ClN4O4
Molecular Weight:
426.9
Package Type:
Plastic Vial
Product Description:
E7080 is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. It is most potent against VEGFR2(KDR)/VEGFR3(Flt-4), with IC(50) values of 4nM and 5.2nM respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase: J. Matsui, et al.; Clin. Cancer Res. 14, 5459 (2008)