RG7422
| Code | Size | Price |
|---|
| SYN-1150-M100 | 100 mg | Enquire |
Quantity:
| SYN-1150-M001 | 1 mg | £127.00 |
Quantity:
| SYN-1150-M005 | 5 mg | £186.00 |
Quantity:
| SYN-1150-M010 | 10 mg | £303.00 |
Quantity:
| SYN-1150-M050 | 50 mg | £889.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
GDC-0980
Appearance:
Solid.
CAS:
1032754-93-0
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
InChiKey:
YOVVNQKCSKSHKT-HNNXBMFYSA-N
Long Description:
Chemical. CAS: 1032754-93-0. Formula: C23H30N8O3S. MW: 498.6. GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC(50) values of 5, 27, 7, and 14nM for PI3Kalpha-delta respectively. It inhibits mTOR with a Ki of 17nM.
Molecular Formula:
C23H30N8O3S
Molecular Weight:
498.6
Package Type:
Plastic Vial
Product Description:
GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC(50) values of 5, 27, 7, and 14nM for PI3Kalpha-delta respectively. It inhibits mTOR with a Ki of 17nM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer: D.P. Sutherlin, et al.; J. Med. Chem. 54, 7579 (2011)
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