BMS-540215
| Code | Size | Price |
|---|
| SYN-1134-M100 | 100 mg | Enquire |
Quantity:
| SYN-1134-M001 | 1 mg | £127.00 |
Quantity:
| SYN-1134-M005 | 5 mg | £186.00 |
Quantity:
| SYN-1134-M010 | 10 mg | £350.00 |
Quantity:
| SYN-1134-M050 | 50 mg | £1,111.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Brivanib; BMS540215
Appearance:
Solid.
CAS:
649735-46-6
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1
InChiKey:
WCWUXEGQKLTGDX-LLVKDONJSA-N
Long Description:
Chemical. CAS: 649735-46-6. Formula: C19H19FN4O3. MW: 370.4. BMS-540215 is an ATP-competitive inhibitor of human VEGFR-2, with an IC(50) of 25nM and Ki of 26nM. BMS-540215 also showed good selectivity for FGFR-1 (IC(50) of 48nM), FGFR-2 (IC(50) of 125nM), and FGFR-3 (IC(50) of 68nM).
Molecular Formula:
C19H19FN4O3
Molecular Weight:
370.4
Package Type:
Plastic Vial
Product Description:
BMS-540215 is an ATP-competitive inhibitor of human VEGFR-2, with an IC(50) of 25nM and Ki of 26nM. BMS-540215 also showed good selectivity for FGFR-1 (IC(50) of 48nM), FGFR-2 (IC(50) of 125nM), and FGFR-3 (IC(50) of 68nM).
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215): Z.W. Cai, et al.; J. Med. Chem. 51, 1976 (2008)