SGX-523
| Code | Size | Price |
|---|
| SYN-1155-M100 | 100 mg | Enquire |
Quantity:
| SYN-1155-M001 | 1 mg | £127.00 |
Quantity:
| SYN-1155-M005 | 5 mg | £203.00 |
Quantity:
| SYN-1155-M010 | 10 mg | £332.00 |
Quantity:
| SYN-1155-M050 | 50 mg | £976.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
SGX523
Appearance:
Solid.
CAS:
1072116-01-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H303, H317, H333
InChi:
InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
InChiKey:
BCZUAADEACICHN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1072116-01-8. Formula: C18H13N7S. MW: 359.4. SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase.
Molecular Formula:
C18H13N7S
Molecular Weight:
359.4
Package Type:
Plastic Vial
Precautions:
P261, P272, P280, P302, P352, P333, P313, P321, P363, P501
Product Description:
SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo: S.G. Buchanan, et al.; Mol. Cancer Ther. 8, 3181 (2009)
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