Ki20227
| Code | Size | Price |
|---|
| SYN-1049-M100 | 100 mg | Enquire |
Quantity:
| SYN-1049-M001 | 1 mg | £127.00 |
Quantity:
| SYN-1049-M005 | 5 mg | £203.00 |
Quantity:
| SYN-1049-M010 | 10 mg | £291.00 |
Quantity:
| SYN-1049-M050 | 50 mg | £976.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Ki-20227
Appearance:
Solid.
CAS:
623142-96-1
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29)
InChiKey:
SHPFDGWALWEPGS-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 623142-96-1. Formula: C24H24N4O5S. MW: 480.5. Ki20227 is a c-fms tyrosine kinase inhibitor. It has IC(50) values of 2, 12, 451 and 217nM for c-Fms, VEGFR-2, c-Kit and PDGFRbeta respectively.
Molecular Formula:
C24H24N4O5S
Molecular Weight:
480.5
Package Type:
Plastic Vial
Product Description:
Ki20227 is a c-fms tyrosine kinase inhibitor. It has IC(50) values of 2, 12, 451 and 217nM for c-Fms, VEGFR-2, c-Kit and PDGFRbeta respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model: H. Ohno, et al.; Mol. Cancer Ther. 5, 2634 (2006) | The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model: H. Ohno, et al.; Eur. J. Immunol. 38, 283 (2008) | M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis: Y. Kubota, et al.; J. Exp. Med. 206, 1089 (2009)
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