R406
| Code | Size | Price |
|---|
| SYN-1121-M100 | 100 mg | Enquire |
Quantity:
| SYN-1121-M001 | 1 mg | £127.00 |
Quantity:
| SYN-1121-M005 | 5 mg | £203.00 |
Quantity:
| SYN-1121-M010 | 10 mg | £303.00 |
Quantity:
| SYN-1121-M050 | 50 mg | £1,006.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
R-406
Appearance:
Solid.
CAS:
841290-80-0
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H303, H317, H333
InChi:
InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
InChiKey:
NHHQJBCNYHBUSI-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 841290-80-0. Formula: C22H23FN6O5. MW: 470.5. R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3.
Molecular Formula:
C22H23FN6O5
Molecular Weight:
470.5
Package Type:
Plastic Vial
Precautions:
P261, P272, P280, P302, P352, P333, P313, P321, P363, P501
Product Description:
R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation: S. Braselmann, et al.; J. Pharmacol. Exp. Ther. 319, 998 (2006)
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