CC-401 hydrochloride
| Code | Size | Price |
|---|
| SYN-1028-M100 | 100 mg | Enquire |
Quantity:
| SYN-1028-M001 | 1 mg | £145.00 |
Quantity:
| SYN-1028-M005 | 5 mg | £244.00 |
Quantity:
| SYN-1028-M010 | 10 mg | £373.00 |
Quantity:
| SYN-1028-M050 | 50 mg | £1,234.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
CC401
Appearance:
Solid.
CAS:
1438391-30-0
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H24N6O.ClH/c1-2-9-28(10-3-1)11-12-29-18-6-4-5-16(13-18)21-19-14-17(22-23-15-24-27-22)7-8-20(19)25-26-21;/h4-8,13-15H,1-3,9-12H2,(H,25,26)(H,23,24,27);1H
InChiKey:
OIBVXKYKWOUGAO-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1438391-30-0. Formula: C22H24N6O . HCl. MW: 388.4 . 36.5. CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least 40-fold selectivity for JNK compared with other related kinases, including: p38, ERK, IKK2, PKC, Lck, and ZAP70. CC-401 acts to inhibit JNK signaling by competitive binding to the adenosine triphosphate-binding site in the active, phosphorylated, form of JNK, resulting in inhibition of the phosphorylation of JNK targets, such as the amino-terminal activation domain of the transcription factor, c-Jun. In cell-based assays, 1-5 muM CC-401 provides specific JNK inhibition.
Molecular Formula:
C22H24N6O . HCl
Molecular Weight:
388.4 . 36.5
Package Type:
Plastic Vial
Product Description:
CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least 40-fold selectivity for JNK compared with other related kinases, including: p38, ERK, IKK2, PKC, Lck, and ZAP70. CC-401 acts to inhibit JNK signaling by competitive binding to the adenosine triphosphate-binding site in the active, phosphorylated, form of JNK, resulting in inhibition of the phosphorylation of JNK targets, such as the amino-terminal activation domain of the transcription factor, c-Jun. In cell-based assays, 1-5 muM CC-401 provides specific JNK inhibition.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis: F.Y. Ma, et al.; J. Am. Soc. Nephrol. 18, 472 (2007)
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