GSK-A1
| Code | Size | Price |
|---|
| SYN-1219-M100 | 100 mg | Enquire |
Quantity:
| SYN-1219-M050 | 50 mg | Enquire |
Quantity:
| SYN-1219-M001 | 1 mg | £151.00 |
Quantity:
| SYN-1219-M005 | 5 mg | £303.00 |
Quantity:
| SYN-1219-M010 | 10 mg | £467.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short Term: +4°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
5-(2-Amino-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide; GSKA1
Appearance:
Solid.
CAS:
1416334-69-4
EClass:
32160000
Form (Short):
liquid
Hazards:
H303, H317, H333
InChi:
InChI=1S/C29H27FN6O4S/c1-39-28-27(41(37,38)34-24-5-3-2-4-23(24)30)17-20(18-32-28)19-6-11-25-26(16-19)36(29(31)33-25)22-9-7-21(8-10-22)35-12-14-40-15-13-35/h2-11,16-18,34H,12-15H2,1H3,(H2,31,33)
InChiKey:
AJOGHKUZDLYXKS-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1416334-69-4. Formula: C29H27FN6O4S. MW: 574.6. GSK-A1 is a potent PI4KA inhibitor with an IC50 of about 3nM in vitro using HEK-AT1 cells. Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.
Molecular Formula:
C29H27FN6O4S
Molecular Weight:
574.6
Package Type:
Plastic Vial
Product Description:
GSK-A1 is a potent PI4KA inhibitor with an IC50 of about 3nM in vitro using HEK-AT1 cells. Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels: N. Bojjireddy, et al.; J. Biol. Chem. 289, 6120 (2014)
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