Brivanib alaninate
| Code | Size | Price |
|---|
| SYN-1135-M100 | 100 mg | Enquire |
Quantity:
| SYN-1135-M001 | 1 mg | £180.00 |
Quantity:
| SYN-1135-M005 | 5 mg | £291.00 |
Quantity:
| SYN-1135-M010 | 10 mg | £420.00 |
Quantity:
| SYN-1135-M050 | 50 mg | £1,064.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
BMS-582664
Appearance:
Solid.
CAS:
649735-63-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H24FN5O4/c1-11-7-15-16(27-11)5-6-17(19(15)23)32-21-20-13(3)18(8-28(20)26-10-25-21)30-9-12(2)31-22(29)14(4)24/h5-8,10,12,14,27H,9,24H2,1-4H3/t12-,14+/m1/s1
InChiKey:
LTEJRLHKIYCEOX-OCCSQVGLSA-N
Long Description:
Chemical. CAS: 649735-63-7. Formula: C22H24FN5O4. MW: 441.5. Brivanib inhibits VEGFR-2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM.
Molecular Formula:
C22H24FN5O4
Molecular Weight:
441.5
Package Type:
Plastic Vial
Product Description:
Brivanib inhibits VEGFR-2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist: M. Ayers, et al.; Cancer Res. 67, 6899 (2007)