PD-173955-Analog1
| Code | Size | Price |
|---|
| SYN-1062-M100 | 100 mg | Enquire |
Quantity:
| SYN-1062-M050 | 50 mg | Enquire |
Quantity:
| SYN-1062-M001 | 1 mg | £186.00 |
Quantity:
| SYN-1062-M005 | 5 mg | £420.00 |
Quantity:
| SYN-1062-M010 | 10 mg | £654.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
PD173955-Analog1
Appearance:
Solid.
CAS:
185039-99-0
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C21H14Cl2N4O3/c1-27-18-12(9-14(19(27)28)17-15(22)6-3-7-16(17)23)10-24-21(26-18)25-13-5-2-4-11(8-13)20(29)30/h2-10H,1H3,(H,29,30)(H,24,25,26)
InChiKey:
RBURTLAMOSHNGX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 185039-99-0. Formula: C21H14Cl2N4O3. MW: 441.3. PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively.
Molecular Formula:
C21H14Cl2N4O3
Molecular Weight:
441.3
Package Type:
Plastic Vial
Product Description:
PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Src activation regulates anoikis in human colon tumor cell lines: T.C Windham, et al.; Oncogene 21, 7797 (2002) | New effective inhibitors of the Abelson kinase: G.A. Kraus, et al.; Bioorg. Med. Chem. 18, 6316 (2010)
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