NVP-BSK805 dihydrochloride
| Code | Size | Price |
|---|
| SYN-1136-M100 | 100 mg | Enquire |
Quantity:
| SYN-1136-M001 | 1 mg | £203.00 |
Quantity:
| SYN-1136-M005 | 5 mg | £303.00 |
Quantity:
| SYN-1136-M010 | 10 mg | £420.00 |
Quantity:
| SYN-1136-M050 | 50 mg | £1,123.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
NVPBSK805
Appearance:
Solid.
CAS:
1092499-93-8 (free base)
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C27H28F2N6O.2ClH/c28-23-12-18(13-24(29)22(23)17-34-8-10-36-11-9-34)21-2-1-3-25-27(21)33-26(15-31-25)19-14-32-35(16-19)20-4-6-30-7-5-20;;/h1-3,12-16,20,30H,4-11,17H2;2*1H
InChiKey:
NUOCAPALWRHKCU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1092499-93-8 (free base). Formula: C27H28F2N6O . 2HCl. MW: 490.6 . 72.9. NVP-BSK805 is a potent and selective quinoxaline JAK2 inhibitor with IC(50) values of 0.48, 0.56 and 0.58nM for JAK2 JH1, FL JAK (V617F) and FL JAK2 wt, respectively.
Molecular Formula:
C27H28F2N6O . 2HCl
Molecular Weight:
490.6 . 72.9
Package Type:
Plastic Vial
Product Description:
NVP-BSK805 is a potent and selective quinoxaline JAK2 inhibitor with IC(50) values of 0.48, 0.56 and 0.58nM for JAK2 JH1, FL JAK (V617F) and FL JAK2 wt, respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805: F. Baffert, et al.; Mol. Cancer Ther. 9, 1945 (2010) | Effects of Jak2 Type 1 Inhibitors NVP-BSK805 and NVP-BVB808 on Jak2 Mutation-Positive and Bcr-Abl-Positive Cell Lines: F. Ringel, et al.; Acta Haematol. 132, 75 (2014)
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