PD-173955
| Code | Size | Price |
|---|
| SYN-1061-M100 | 100 mg | Enquire |
Quantity:
| SYN-1061-M050 | 50 mg | Enquire |
Quantity:
| SYN-1061-M001 | 1 mg | £203.00 |
Quantity:
| SYN-1061-M005 | 5 mg | £332.00 |
Quantity:
| SYN-1061-M010 | 10 mg | £514.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
PD173955
Appearance:
Solid.
CAS:
260415-63-2
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
InChiKey:
VAARYSWULJUGST-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 260415-63-2. Formula: C21H16Cl2N4OS. MW: 443.4. PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug.
Molecular Formula:
C21H16Cl2N4OS
Molecular Weight:
443.4
Package Type:
Plastic Vial
Product Description:
PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571): B. Nagar, et al.; Cancer Res. 62, 4236 (2002)
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