JNJ-38158471
| Code | Size | Price |
|---|
| SYN-1133-M100 | 100 mg | Enquire |
Quantity:
| SYN-1133-M050 | 50 mg | Enquire |
Quantity:
| SYN-1133-M001 | 1 mg | £233.00 |
Quantity:
| SYN-1133-M005 | 5 mg | £461.00 |
Quantity:
| SYN-1133-M010 | 10 mg | £643.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
JNJ38158471
Appearance:
Solid.
CAS:
951151-97-6
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C15H17ClN6O3/c1-3-18-15(23)22-12-5-4-9(6-11(12)16)25-14-10(7-21-24-2)13(17)19-8-20-14/h4-8H,3H2,1-2H3,(H2,17,19,20)(H2,18,22,23)/b21-7+
InChiKey:
BJHCYTJNPVGSBZ-QPSGOUHRSA-N
Long Description:
Chemical. CAS: 951151-97-6. Formula: C15H17ClN6O3. MW: 364.8. JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (>1µM) against VEGFR-1 and VEGFR-3.
Molecular Formula:
C15H17ClN6O3
Molecular Weight:
364.8
Package Type:
Plastic Vial
Product Description:
JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (>1µM) against VEGFR-1 and VEGFR-3.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo: K.R. LaMontagne, et al.; Angiogenesis 12, 287 (2009)