PF-4618433
| Code | Size | Price |
|---|
| SYN-1163-M100 | 100 mg | Enquire |
Quantity:
| SYN-1163-M050 | 50 mg | Enquire |
Quantity:
| SYN-1163-M001 | 1 mg | £233.00 |
Quantity:
| SYN-1163-M005 | 5 mg | £461.00 |
Quantity:
| SYN-1163-M010 | 10 mg | £719.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
PF4618433
Appearance:
Solid.
CAS:
1166393-85-6
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C24H27N7O2/c1-16-7-9-18(10-8-16)31-22(13-20(30-31)24(2,3)4)27-23(32)26-21-12-17(28-29-21)15-33-19-6-5-11-25-14-19/h5-14H,15H2,1-4H3,(H3,26,27,28,29,32)
InChiKey:
NJARPUHZDSAXPL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1166393-85-6. Formula: C24H27N7O2. MW: 445.5. Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.
Molecular Formula:
C24H27N7O2
Molecular Weight:
445.5
Package Type:
Plastic Vial
Product Description:
Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design: S. Han, et al.; J. Biol. Chem. 284, 13193 (2009) | Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors: S.K. Bhattacharya, et al.; Bioorg. Med. Chem. Lett. 22, 7523 (2012) | Non-canonical pathway induced by Wnt3a regulates b-catenin via Pyk2 in differentiating human neural progenitor cells: V.A.N. Talabattula, et al.; BBRC 491, 40 (2017)
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