SB-242235
| Code | Size | Price |
|---|
| SYN-1076-M100 | 100 mg | Enquire |
Quantity:
| SYN-1076-M050 | 50 mg | Enquire |
Quantity:
| SYN-1076-M001 | 1 mg | £233.00 |
Quantity:
| SYN-1076-M005 | 5 mg | £461.00 |
Quantity:
| SYN-1076-M010 | 10 mg | £719.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
SB-242235
Appearance:
Solid.
CAS:
193746-75-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C19H20FN5O/c1-26-19-22-11-8-16(24-19)18-17(13-2-4-14(20)5-3-13)23-12-25(18)15-6-9-21-10-7-15/h2-5,8,11-12,15,21H,6-7,9-10H2,1H3
InChiKey:
PDTYLGXVBIWRIM-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 193746-75-7. Formula: C19H20FN5O. MW: 353.4. The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. SB-242235 is a potent and moderately selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. SB-242235 exhibits good oral availability in preclinical studies and has micromolar or submicomolar in vivo IC(50) values. However it is clear from studies examining SB-242235 effects on metabolism, for instance in chondrocytes and human cartilage that SB-242235 effects can be pleiotropic between species and that care must be taken when studying the interactions of multi-target inhibitors such as SB-242235.
Molecular Formula:
C19H20FN5O
Molecular Weight:
353.4
Package Type:
Plastic Vial
Product Description:
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. SB-242235 is a potent and moderately selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. SB-242235 exhibits good oral availability in preclinical studies and has micromolar or submicomolar in vivo IC(50) values. However it is clear from studies examining SB-242235 effects on metabolism, for instance in chondrocytes and human cartilage that SB-242235 effects can be pleiotropic between species and that care must be taken when studying the interactions of multi-target inhibitors such as SB-242235.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis: A.M. Badger, et al.; Arthritis Rheum. 43, 175 (2000) | Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity: J.L. Adams, et al.; Bioorg. Med. Chem. Lett. 11, 2867 (2001) | SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics: K.W. Ward, et al.; Xenobiotica 32, 221 (2002)
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