Akt-I-1
| Code | Size | Price |
|---|
| SYN-1005-M100 | 100 mg | Enquire |
Quantity:
| SYN-1005-M050 | 50 mg | Enquire |
Quantity:
| SYN-1005-M001 | 1 mg | £238.00 |
Quantity:
| SYN-1005-M005 | 5 mg | £461.00 |
Quantity:
| SYN-1005-M010 | 10 mg | £719.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
AktI1
Appearance:
Solid.
CAS:
473382-39-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H30N6/c1-22(2,15-27(3)4)14-23-20-18(16-11-8-12-16)13-19-24-25-21(28(19)26-20)17-9-6-5-7-10-17/h5-7,9-10,13,16H,8,11-12,14-15H2,1-4H3,(H,23,26)
InChiKey:
FKCXKEHHZXEWGP-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 473382-39-7. Formula: C22H30N6. MW: 378.5. The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, AKT-I-1 blocked the phosphorylation and activation of AKT1 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.
Molecular Formula:
C22H30N6
Molecular Weight:
378.5
Package Type:
Plastic Vial
Product Description:
The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, AKT-I-1 blocked the phosphorylation and activation of AKT1 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors: S.F. Barnett, et al.; Biochem. J. 385, 399 (2005)
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