RO495
| Code | Size | Price |
|---|
| SYN-1128-M100 | 100 mg | Enquire |
Quantity:
| SYN-1128-M050 | 50 mg | Enquire |
Quantity:
| SYN-1128-M001 | 1 mg | £238.00 |
Quantity:
| SYN-1128-M005 | 5 mg | £578.00 |
Quantity:
| SYN-1128-M010 | 10 mg | £824.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
RO-495
Appearance:
Solid.
CAS:
1258296-60-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C17H14Cl2N6O/c1-9-7-14(25-17(20)22-9)24-13-8-10(5-6-21-13)23-16(26)15-11(18)3-2-4-12(15)19/h2-8H,1H3,(H4,20,21,22,23,24,25,26)
InChiKey:
LNGDQKGREFSTHB-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1258296-60-4. Formula: C17H14Cl2N6O. MW: 389.2. RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology.
Molecular Formula:
C17H14Cl2N6O
Molecular Weight:
389.2
Package Type:
Plastic Vial
Product Description:
RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Identification of potent Yes1 kinase inhibitors using a library screening approach: P.R. Patel, et al.; Bioorg. Med. Chem. Lett. 23, 4398 (2013)