AZD-26
| Code | Size | Price |
|---|
| SYN-1160-M100 | 100 mg | Enquire |
Quantity:
| SYN-1160-M050 | 50 mg | Enquire |
Quantity:
| SYN-1160-M001 | 1 mg | £238.00 |
Quantity:
| SYN-1160-M005 | 5 mg | £461.00 |
Quantity:
| SYN-1160-M010 | 10 mg | £719.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
AZD26
Appearance:
Solid.
CAS:
1357158-81-6
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H21N3O/c23-21(26)17-13-19(15-5-2-1-3-6-15)20(25-14-17)16-7-9-18(10-8-16)22(24)11-4-12-22/h1-3,5-10,13-14H,4,11-12,24H2,(H2,23,26)
InChiKey:
GIRZDHCBMNHMEH-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1357158-81-6. Formula: C22H21N3O. MW: 343.4. AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.
Molecular Formula:
C22H21N3O
Molecular Weight:
343.4
Package Type:
Plastic Vial
Product Description:
AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Diverse heterocyclic scaffolds as allosteric inhibitors of AKT: J.G. Kettle, et al.; J. Med. Chem. 55, 1261 (2012)
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