BMS-2
| Code | Size | Price |
|---|
| SYN-1022-M010 | 10 mg | Enquire |
Quantity:
| SYN-1022-M001 | 1 mg | £303.00 |
Quantity:
| SYN-1022-M005 | 5 mg | £889.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
BMS2
Appearance:
Solid.
CAS:
888719-03-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C25H16F2N4O3/c26-15-3-6-17(7-4-15)31-13-1-2-19(25(31)33)24(32)30-16-5-8-22(20(27)14-16)34-21-10-12-29-23-18(21)9-11-28-23/h1-14H,(H,28,29)(H,30,32)
InChiKey:
OBSFXHDOLBYWRJ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 888719-03-7. Formula: C25H16F2N4O3. MW: 458.4. BMS-2 is a potent MET kinase inhibitor with an IC(50) value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC(50) values of 4nM and 27nM respectively.
Molecular Formula:
C25H16F2N4O3
Molecular Weight:
458.4
Package Type:
Plastic Vial
Product Description:
BMS-2 is a potent MET kinase inhibitor with an IC(50) value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC(50) values of 4nM and 27nM respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities: K.S. Kim, et al.; J. Med. Chem. 51, 5330 (2008)