R428
| Code | Size | Price |
|---|
| SYN-1131-M100 | 100 mg | Enquire |
Quantity:
| SYN-1131-M050 | 50 mg | Enquire |
Quantity:
| SYN-1131-M001 | 1 mg | £303.00 |
Quantity:
| SYN-1131-M005 | 5 mg | £771.00 |
Quantity:
| SYN-1131-M010 | 10 mg | £1,416.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
R-428
Appearance:
Solid.
CAS:
1037624-75-1
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1
InChiKey:
KXMZDGSRSGHMMK-VWLOTQADSA-N
Long Description:
Chemical. CAS: 1037624-75-1. Formula: C30H34N8. MW: 506.6. R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Reported IC(50) values are 11-14nM .
Molecular Formula:
C30H34N8
Molecular Weight:
506.6
Package Type:
Plastic Vial
Product Description:
R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Reported IC(50) values are 11-14nM .
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer: S.J. Holland, et al.; Cancer Res. 70, 1544 (2010) | Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors: A. Mollard, et al.; ACS Med. Chem. Lett. 2, 907 (2011)
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