Jak/Src Inhibitor 1 . hydrochloride
| Code | Size | Price |
|---|
| AG-CR1-3647-M001 | 1 mg | £120.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Debio 0617B . HCl; N-(4-Chloro-3-(2-((4-(methyl-carbamoyl)phenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl)-4-(trifluoromethyl)picolinamide
Appearance:
Yellow solid.
CAS:
1332329-27-7 (parent)
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C28H23ClF3N7O2.ClH/c1-33-25(40)16-2-4-19(5-3-16)37-27-35-14-17-15-39(11-9-22(17)38-27)24-13-20(6-7-21(24)29)36-26(41)23-12-18(8-10-34-23)28(30,31)32;/h2-8,10,12-14H,9,11,15H2,1H3,(H,33,40)(H,36,41)(H,35,37,38);1H
InChiKey:
VQUNOHCOLZKQJY-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1332329-27-7 (parent). Formula: C28H23ClF3N7O2 . HCl. MW: 582.0 . 36.5. Multi-kinase inhibitor with potent antiproliferative activity. Potent STAT3/5 inhibitor in vitro and in vivo. Combined inhibitor of pSTAT3 proteins such as JAK, SRC, ABL and class III/V receptor tyrosine kinases (RTK), including FLT3, c-KIT, CSF1-R, PDGFRs and VEGFRs, in nanomolar range.
MDL:
MFCD30749186
Molecular Formula:
C28H23ClF3N7O2 . HCl
Molecular Weight:
582.0 . 36.5
Package Type:
Vial
Product Description:
Multi-kinase inhibitor with potent antiproliferative anti-migratory activities. Potent STAT3/5 inhibitor in vitro and in vivo. Combined inhibitor of key kinases phosphorylating STAT3 and STAT5 proteins such as JAK, SRC, ABL families of kinases, and class III/V receptor tyrosine kinases (RTK), including FLT3, c-KIT, CSF1-R, PDGFRs and VEGFRs, in nanomolar range.
Purity:
>97% (HPLC)
SMILES:
O=C(NC)C(C=C1)=CC=C1NC2=NC=C3C(CCN(C4=CC(NC(C5=NC=CC(C(F)(F)F)=C5)=O)=CC=C4Cl)C3)=N2.Cl
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Debio 0617B inhibits growth of STAT3-driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases: M. Murone, et al.; Mol. Cancer Ther. 15, 2334 (2016) | The multi-kinase inhibitor Debio 0617B reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells: M. Murone, et al.; Mol. Cancer Ther. (Epub ahead of print) (2017)