Fipronil
| Code | Size | Price |
|---|
| AG-CR1-3648-M100 | 100 mg | £60.00 |
Quantity:
| AG-CR1-3648-G001 | 1 g | £105.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
+4°C
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Fluocyanobenpyrazole; Termidor; 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethanesulfinyl)-1H-pyrazole-3-carbonitrile
Appearance:
White to yellow solid.
CAS:
120068-37-3
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Hazards:
H301, H311, H331, H372, H410
InChi:
InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2
InChiKey:
ZOCSXAVNDGMNBV-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 120068-37-3. Formula: C12H4Cl2F6N4OS. MW: 437.2. Alzheimer inducing agent (Alzheimerogen). Potent GABA receptor alpha-4 subunit and beta-3 subunit inhibitor. Broad-range insecticide. Blocks GABA A-gated chloride channels and glutamate-activated chloride channels (GluCls) in the central nervous system, resulting in overexcitation of the insects nervous system and muscles. Induces oxidative stress in mouse kidney and brain. Increases CYP1A1, CYP2B6, CYP3A4 and CYP3A5 transcript, protein and enzyme activity levels.
MDL:
MFCD00867812
Molecular Formula:
C12H4Cl2F6N4OS
Molecular Weight:
437.2
Package Type:
Plastic Vial
PG:
III
Precautions:
P273, P301, P310, P302, P352, P304, P340, P305, P351, P338
Product Description:
Alzheimer inducing agent (Alzheimerogen). Potent GABA receptor alpha-4 subunit and beta-3 subunit inhibitor. Broad-range insecticide. Blocks GABA A-gated chloride channels and glutamate-activated chloride channels (GluCls) in the central nervous system, resulting in overexcitation of the insects nervous system and muscles. Induces oxidative stress in mouse kidney and brain. Increases CYP1A1, CYP2B6, CYP3A4 and CYP3A5 transcript, protein and enzyme activity levels.
Purity:
>98% (NMR)
Signal word:
Danger
SMILES:
ClC1=C(N2N=C(C#N)C(S(C(F)(F)F)=O)=C2N)C(Cl)=CC(C(F)(F)F)=C1
Solubility Chemicals:
Soluble in DMSO, methanol, ethanol or acetone. Insoluble in water.
Transportation:
Excepted Quantity
UN Nummer:
UN 2811
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
Action of Phenylpyrazole Insecticides at the GABA-Gated Chloride Channel: L.M. Cole, et al.; Pestic. Biochem. Physiol. 46, 47 (1993) | Actions of the insecticide fipronil, on dieldrin-sensitive and -resistant GABA receptors of Drosophila melanogaster: A.M. Hosie, et al.; Br. J. Pharmacol. 115, 909 (1995) | Ion channels: molecular targets of neuroactive insecticides: V. Raymond-Delpech, et al.; Invert. Neurosci. 5, 119 (2005) | Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals: T. Narahashi, et al.: Pestic. Biochem. Physiol. 97, 149 (2010) | Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C: P.C. Badgujar, et al.; Pestic. Biochem. Physiol. 118, 10 (2015) | Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration: B.L. Pearson, et al.; Nat. Commun. (2015) | Specific triazine herbicides induce amyloid-beta42 production: E. Portelius, et al.; J. Alzheimers Dis. 54, 1593 (2016) | Impact of environmental chemicals on the transcriptome of primary human hepatocytes: Potential for health effects: R.D. Mitchell, et al.; J. Biochem. Mol. Toxicol. 30, 375 (2016)
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