Fc (human):CD137L, Soluble (human) (rec.)
| Code | Size | Price |
|---|
| AG-40B-0173-C010 | 10 ug | £210.00 |
Quantity:
| AG-40B-0173-3010 | 3 x 10 ug | £410.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
-20°C
Further Information
Alternate Names/Synonyms:
4-1BBL; TNFSF9
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. The receptor-binding domain of human CD137L (aa 85-254) is fused at the N-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Lyophilized. Contains PBS. Purity: >90% (SDS-PAGE). The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes and in T and B cell co-stimulation and modulation of the immune response.
Molecular Weight:
~46kDa (SDS-PAGE)
NCBI, Uniprot Number:
P41273
Package Type:
Plastic Vial
Product Description:
The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes and in T and B cell co-stimulation and modulation of the immune response.
Purity:
>90% (SDS-PAGE)
Sequence:
The receptor-binding domain of human CD137L (aa 85-254) is fused at the N-terminus to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
Specificity:
Binds to human CD137 receptor.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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