Anti-Human CD11c Monoclonal Antibody, Unconjugated Clone BU15

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Diaclone
Product Code: 853.383.020
Product Group: Primary Antibodies
Supplier: Diaclone
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853.383.020100ug/100ul£375.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: BU15
Regulatory Status: RUO
Target Species: Human
Applications:
  • Flow Cytometry
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
Storage:
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Documents

Further Information

Antigen:
CD11c / Integrin a X
Antigen Synonyms:
Integrin a X
Conjugate:
Purified
Format:
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Immunisation:
Dendritic cells of synovial fluid
Reactivity:
Human
Research Area:
Cell Adhesion,CD Markers
Specificity:
The antibody BU15 reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
Working Dilution:
We recommend that each laboratory determine an optimum working titre for use in its particular application.

References

  1. Angel C.E. et al., Int Immunol., 2007;19(11):1271-9. CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts.. https://www.ncbi.nlm.nih.gov/pubmed/17804688
  2. Bullard D.C. et al., Am J Pathol., 2007;170(6):2001-8. p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis.. https://www.ncbi.nlm.nih.gov/pubmed/17525267
  3. Gang J. et al., Mol Cells., 2007;24(2):240-6. Identification of critical residues for plasminogen binding by the alphaX I-domain of the beta2 integrin, alphaXbeta2.. https://www.ncbi.nlm.nih.gov/pubmed/17978577
  4. Hogg N. et al., Eur J Immunol., 1986;16(3):240-8. The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.. https://www.ncbi.nlm.nih.gov/pubmed/3456894
  5. Leucocyte Typing V. Schlossman S. et al. (Eds.), Oxford University Press (1995).. .
  6. Leucocyte Typing VI. Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).. .
  7. Leukocyte Typing III., McMichael A. J. et al (Eds.), Oxford University Press (1987). .
  8. Myou S. et al., Immunology, 2002;107(1):77-85. Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.. https://www.ncbi.nlm.nih.gov/pubmed/12225365
  9. Rezzonico R. et al., Blood, 2001;97(10):2932-40. Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.. https://www.ncbi.nlm.nih.gov/pubmed/11342414
  10. Sadhu C. et al., J Immunoassay Immunochem., 2008;29(1):42-57. Novel tools for functional analysis of CD11c: activation-specific, activation-independent, and activating antibodies.. https://www.ncbi.nlm.nih.gov/pubmed/18080879
  11. Sadhu C. et al., J. Leukoc. Biol., 2007; 81(6):1395-403. CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity.. https://www.ncbi.nlm.nih.gov/pubmed/17389580
  12. Trowald-Wigh G. et al., Vet Immunol. Immunopathol. ,1993;38(3-4) :297-310. Canine neutrophil adhesion proteins and Fc-receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry.. https://www.ncbi.nlm.nih.gov/pubmed/8291207
  13. Van der Vieren M. et al., Immunity, 1995;3(6):683-90. A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.. https://www.ncbi.nlm.nih.gov/pubmed/8777714
  14. Vorup-Jensen T. et al., J Biol Chem. ,2007;282(42):30869-77. Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin.. https://www.ncbi.nlm.nih.gov/pubmed/17699512