TBB
| Code | Size | Price |
|---|
| AG-CR1-3660-M005 | 5 mg | £40.00 |
Quantity:
| AG-CR1-3660-M025 | 25 mg | £105.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
Short Term: +4°C. Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
4,5,6,7-Tetrabromo-2-azabenzimidazole; Tetrabromobenzotriazole; NSC 231634; TBBt
Appearance:
Solid.
CAS:
17374-26-4
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChiKey:
OMZYUVOATZSGJY-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 17374-26-4. Formula: C6HBr4N3. MW: 434.7. Synthetic. ATP/GTP-competitive cell permeable casein kinase II (CK2) inhibitor (IC50=0.9µM for rat liver. Less potently inhibits CCK2/cyclin A, GSK3beta and phosphorylase kinase (IC50=15.6, 11.2 and 8.7µM, respectively). Binds to the Val66 residue of CK2 and inhibits the binding of ATP/GTP. Moderate DYRK1A inhibitor (IC50=4.4µM). Induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
MDL:
MFCD06411399
Molecular Formula:
C6HBr4N3
Molecular Weight:
434.7
Package Type:
Plastic Vial
Product Description:
ATP/GTP-competitive cell permeable casein kinase II (CK2) inhibitor (IC50=0.9µM for rat liver. Less potently inhibits CCK2/cyclin A, GSK3beta and phosphorylase kinase (IC50=15.6, 11.2 and 8.7µM, respectively). Binds to the Val66 residue of CK2 and inhibits the binding of ATP/GTP. Moderate DYRK1A inhibitor (IC50=4.4µM). Induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
Purity:
>98% (HPLC)
SMILES:
BrC1=C(Br)C(Br)=C(Br)C2=C1N=NN2
Solubility Chemicals:
Soluble in DMSO (20mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'): S. Sarno, et al.; FEBS Lett. 496, 44 (2001) | Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells: M. Ruzzene, et al.; Biochem. J. 364, 41 (2002) | Alternative binding modes of an inhibitor to two different kinases: E. De Moliner, et al. Eur. J. Biochem. 270, 3174 (2003) | Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole: M.A. Pagano, et al.; J. Med. Chem. 47, 6239 (2004) | Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2: P. Zien, et al.; Biochim. Biophys. Acta 1754, 271 (2005) | The selectivity of inhibitors of protein kinase CK2: An update: M.A. Pagano, et al.; Biochem. J. 415, 353 (2008)
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