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4-Aminobutanoic acid

Product Code:
 
CDX-G0043
Product Group:
 
Inhibitors and Activators
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short Term: +20°C. Long Term: +20°C
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Chemical Structure
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Chemical Structure

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CDX-G0043-G500500 g£169.00
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Further Information

Alternate Names/Synonyms:
4-Aminobutanoic acid; Piperidic acid; Piperidinic acid; gamma-Aminobutyric acid
Appearance:
White crystals or crystalline powder.
CAS:
56-12-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChiKey:
BTCSSZJGUNDROE-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 56-12-2. Formula: C4H9NO2. MW: 103.12. Synthetic. An amino acid that functions as the major inhibitory neurotransmitter in the mammalian central nervous system and also functions as a neuromodulator in some peripheral tissues. GABAA and GABAB receptor agonist that increases Cl? conductance. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation and anaesthetics. GABA can also influence heart rate and blood pressure and function as a immunomodulator.
MDL:
MFCD00008226
Molecular Formula:
C4H9NO2
Molecular Weight:
103.12
Package Type:
Vial
Product Description:
An amino acid that functions as the major inhibitory neurotransmitter in the mammalian central nervous system and also functions as a neuromodulator in some peripheral tissues. GABAA and GABAB receptor agonist that increases Cl? conductance. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation and anaesthetics. GABA can also influence heart rate and blood pressure and function as a immunomodulator.
Purity:
>99% (Titration)
SMILES:
OC(CCCN)=O
Solubility Chemicals:
Soluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +20°C.

References

(1) H.A. Al-Wadei, et al.; Mol. Nutr. Food Res. 55, 1745 (2011) | (2) Z. Jin, et al.; Amino Acids 45, 87 (2013) | (3) C.A. Huebner & K. Holthoff; Front. Cell Neurosci. 7, 177 (2013) | (4) T. Crowley, et al.; Brain Behav. Immun. 54, 260 (2016) | (5) N.X. Tritsch, et al.; Nat. Rev. Neurosci. 17, 139 (2016) | (6) R. Mazzoli & E. Pessione; Front. Microbiol. 7, 1934 (2016)