Drosophila Parkin Antibody
| Code | Size | Price |
|---|
| PSI-62-278-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Drosophila (fruit fly)
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
CG10523-PB; isoform B; Cg10523-pc; isoform c; PARKIN; park; parkin;
Application Note:
For WB starting dilution is: 1:1000
Background:
Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.
Background References:
- Zhong,L. et al. J. Biol. Chem. 280 (10), 9425-9430 (2005)
- Pesah,Y. et al. Development 131 (9), 2183-2194 (2004)
- Haywood,A.F. et al. BMC Neurosci 5, 14 (2004)
- Finney,N. et al. J. Biol. Chem. 278 (18), 16054-16058 (2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Drosophila Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-111 amino acids from the N-terminal region of human Drosophila Parkin.
NCBI Gene ID #:
40336
NCBI Official Name:
CG10523-PB, isoform B
NCBI Official Symbol:
Q7KTX7
NCBI Organism:
Drosophila melanogaster
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Protein Accession #:
Q7KTX7
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Swissprot #:
Q7KTX7
User NOte:
Optimal dilutions for each application to be determined by the researcher.