ST6GALNAC1 Antibody

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ProSci
Product Code: PSI-56-398
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-56-398-400ul400ul£626.00
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

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Further Information

Additional Names:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, GalNAc alpha-2,6-sialyltransferase I, ST6GalNAc I, ST6GalNAcI, Sialyltransferase 7A, SIAT7-A, ST6GALNAC1, SIAT7A
Application Note:
For WB starting dilution is: 1:1000
Background:
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).
Background References:
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Hassinen, A., et al. J. Biol. Chem. 285(23):17771-17777(2010)
  • Patani, N., et al. Cancer Genomics Proteomics 5(6):333-340(2008)
  • Olsen, J.V., et al. Cell 127(3):635-648(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ST6GALNAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-57 amino acids from the N-terminal region of human ST6GALNAC1.
NCBI Gene ID #:
55808
NCBI Official Name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
NCBI Official Symbol:
ST6GALNAC1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
69 kDa
Protein Accession #:
Q9NSC7
Protein GI Number:
21759444
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer
Swissprot #:
Q9NSC7
User NOte:
Optimal dilutions for each application to be determined by the researcher.