MLH1 Antibody
| Code | Size | Price |
|---|
| PSI-55-988-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1, COCA2
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
This gene was identified as a locus frequently mutated in
hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog
of the E. coli DNA mismatch repair gene mutL, consistent with the
characteristic alterations in microsatellite sequences
(RER+phenotype) found in HNPCC. Alternative splicing results in
multiple transcript variants encoding distinct isoforms. Additional
transcript variants have been described, but their full-length
natures have not been determined.
Background References:
- Ling, Z.Q., et al. Cancer Lett. 297(2):244-251(2010)
- Qi, Y., et al. J. Biol. Chem. 285(43):33010-33017(2010)
- Borras, E., et al. Cancer Res. 70(19):7379-7391(2010)
- Mangoni, M., et al. Int. J. Radiat. Oncol. Biol. Phys. (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-480 amino acids from the Central region of human MLH1.
NCBI Gene ID #:
4292
NCBI Official Name:
DNA mismatch repair protein Mlh1
NCBI Official Symbol:
MLH1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
Protein Accession #:
P40692
Protein GI Number:
730028
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer
Swissprot #:
P40692
User NOte:
Optimal dilutions for each application to be determined by the researcher.