FADD Antibody
| Code | Size | Price |
|---|
| PSI-60-625-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is an adaptor molecule
that interacts with various cell surface receptors and mediates
cell apoptotic signals. Through its C-terminal death domain, this
protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis
factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it
participates in the death signaling initiated by these receptors.
Interaction of this protein with the receptors unmasks the
N-terminal effector domain of this protein, which allows it to
recruit caspase-8, and thereby activate the cysteine protease
cascade. Knockout studies in mice also suggest the importance of
this protein in early T cell development.
Background References:
- Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010)
- Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
- Papoff, G., et al. Biochim. Biophys. Acta 1803(8):898-911(2010)
- Li, P., et al. J. Biol. Chem. 285(29):22713-22722(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.
NCBI Gene ID #:
8772
NCBI Official Name:
FAS-associated death domain protein
NCBI Official Symbol:
FADD
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
Protein Accession #:
Q13158
Protein GI Number:
2498355
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q13158
User NOte:
Optimal dilutions for each application to be determined by the researcher.